Lc-ms Strategies in Monitoring the Response to Different Therapy

نویسندگان

  • SILVIA IMRE
  • GRIGORE DOGARU
  • LAURIAN VLASE
  • CAMIL EUGEN VARI
  • MARIA TITICA DOGARU
  • CARMEN CĂLDĂRARU
چکیده

Therapeutic drug monitoring is an esential tool for a positive management therapy. The prefered laboratory strategy is immunoassay. Due to the cross-reactivity to other components, alternative approaches, such as LC-MS, are continously under investigation. The paper described briefly the main aspects regarding LC-MS apparatus and technique and recent applications on therapeutic drug monitoring, other than already extensively described applications as in immunosupressing therapy monitoring. Rezumat Monitorizarea farmacoterapiei este un instrument esenţial al unui management terapeutic pozitiv. Strategia de laborator preferată este imunoanaliza. Datorită reactivităţii încrucişate cu alţi componenţi, alte metode sunt în continuă investigare, cum ar fi metoda LC-MS. Lucrarea descrie într-o manieră sumară principalele aspecte privind aparatura şi tehnica LC-MS şi aplicaţii recente ale acesteia în monitorizarea farmacoterapiei, altele decât cele descrise deja în literatura de specialitate, cum ar fi monitorizarea terapiei imunosupresive.

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تاریخ انتشار 2009